Intradermal immunization with combined baculovirus and tumor cell lysate induces effective antitumor immunity in mice
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چکیده
منابع مشابه
Intradermal immunization with combined baculovirus and tumor cell lysate induces effective antitumor immunity in mice.
Although tumor lysate contains all the potential helper and killer epitopes capable of stimulating T cells, it is difficult to use as a cancer vaccine because it suppresses dendritic cell (DC) function. We report that wild-type baculovirus possesses an adjuvant effect to improve the immunogenicity of tumor lysate. When mice were administered CT26 tumor cell lysate combined with baculovirus intr...
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We have utilized a free-solution isoelectric focusing technique (FS-IEF) to obtain chaperone-rich cell lysate (CRCL) fractions from clarified tumor homogenates and have previously reported on their vaccinating potential. To better understand the underlying mechanisms as well as to improve on the immunizing efficacy of tumor-derived chaperone complexes, in the present study we examined the effec...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2013
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2013.2125